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After these corrections are applied to the raw sequence read data, the corrected copy number estimates are locally smoothed to reduce the impact of high-frequency noise.
This value was multiplied by the copy number for a selected assay to arrive at the corrected copy number.
Next, raw values were divided by the raw value of the calibrator (a known single-copy sample included in all runs) to obtain the (corrected) copy numbers.
The final presentation of the corrected copy number data is in the form of a histogram drawn vertically from the figure centerline.
These were used to generate a correction curve by linear regression, and corrected copy number estimates calculated for each sample calculated using this run-specific regression equation.
Positive controls with known copy number in each run were used to generate a correction curve by linear regression, and corrected copy number estimates calculated for each sample calculated using this run-specific regression equation.
This simplified approach relies on a delivery mechanism to provide a corrected copy of the defective gene without removal of the error-containing genomic sequence.
"Now that we have a corrected copy, the original will be slightly more valuable," he said.
There, an engineered virus inserted a corrected copy of the malfunctioning gene into the cells' DNA.
She has said she will issue a corrected copy of the paperback but has not said when.
The highest price heever paid for anything was $65,000 for Shelly's own annotated and corrected copy of "Queen Mab".
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CEO of Professional Science Editing for Scientists @ prosciediting.com