This constitutes a major drawback in its successful application.
Nevertheless, in some cases this high stiffness constitutes a drawback because it could reduce the fatigue resistance offered by these materials, leading to a premature appearance of cracks in the pavement, which decreases its service life.
As this coincidence may not be a rarity in other, differently selected, populations, it constitutes a drawback of this kind of model.
The fact that the binding is nealy irreversible, however, constitutes a drawback in term of the isolation and purification of intact biomolecules.
The highest MCA is found for Mn2PtSn (3.04 meV) but its low TC (374 K) constitutes a drawback.
Since not all cytokines result in a biological response, the potential biological incompatibility of tested compounds constitutes a drawback of our model.
Despite the role of miR-21, miR-203 and miR-205 in cellular processes associated with cancer metastasis, clearly demonstrated when each one is studied independently, their concurrent importance in keratinocyte physiology constitutes a drawback when studying them in regard to proliferation and invasion in the context of squamous cell carcinomas.
This constitutes an important drawback for economic evaluations in the context of public health and health promotion.
For Obama, this constitutes a meaningful shift.
"In M&A terms, this constitutes a recession".
This constitutes a breach of company law.
