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This constellation can be explained by the fact that DR4 expression is rather low on normal liver cells while up-regulated DR4 expression following HCV infection sensitizes liver cells towards TRAIL-mediated apoptosis [ 14, 21].
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First, the TD increases as the number of constellation symbols increases; this can be explained by the higher sensitivity of the higher modulation formats resulting in higher levels of TD.
This phenomenon is more evident for QPSK modulation rather than for 16QAM, and this difference can be explained considering that all QPSK constellation points can be moved in some directions by the ACE algorithm, while for 16QAM the inner points must be immediately restored, and the points on the edges have only one degree of freedom.
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