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This consideration stems from the observation that deficits of the neural retina may be detected even in total absence of retinal microvessel damage.
This consideration stems from two pieces of circumstantial evidence: inhibition of NADH-linked respiration by metformin has been observed in mitochondria, submitochondrial particles [ 7] and immunoprecipitated complex I [ 8], and inhibition of complex I can inhibit respiration [ 9] and lead to activation of AMPK in cells [ 10].
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A second normative consideration stems from the importance given to personal responsibility in contemporary political philosophy.
The latter consideration stems from toxic endpoints being dose-dependent [14,15], and animal models tend to use doses higher than the equivalent human doses.
A further possible consideration stems from the notion that lung tumorigenesis ought to be the cancer risk assessment driver for ingested PAH mixtures.
Another important consideration stems from the observation that the environmental conditions under which fitness assays are performed can profoundly affect the perceived decline in fitness due to MA.
A second consideration stems from the possibility that a substantial portion of the early lineage of duplicate gene evolution evolved in a diploid (between nodes 1 and 2 in Fig. 1B) as a result of the putative allopolyploid origin of the ancestor of Xenopus tetraploids.
To the best of our understanding, this scenario is best compatible both with comparative-genomic results and with more general considerations stemming from the parsimony principle [ 41- 44].
"We will act in the short term to trim expenses, but we won't let short-term considerations stem future growth," said Peter Kann, the chairman and chief executive of Dow Jones.
Such considerations stem from the increasing financial and social costs of damage done by this type of mining activity.
In particular, there might be strong reasons to reject these theories based on considerations stemming from intrinsicality itself.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com