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This conjugation was capable of showing high antileukemic activity by inducing cell cycle arrest and promoting apoptosis regulating activities like nuclear fragmentation.
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Based on the shape of the generators, this conjugation is classified into three types, and corresponding conjugate conditions are investigated.
In this paper, the basic principles of this conjugation are developed.
However, unlike ubiquitin or ubiquitin-like protein modifiers, DSS1 has four critical amino acid residues, three Trp (W) and one Phe (F), involved in its attachment to the targeted proteins, implying that this conjugation is carried out by a particular mechanism (Fig. 5).
This conjugation is not followed by být itself, so future-oriented expressions involving nouns, adjectives, or prepositions (rather than verbs) omit být.
This conjugation is usually considered as a detoxification procedure.
Another reason for this conjugation is interpreted from the FTIR results.
This conjugation is an event to form an autophagosome structure and can be used as an autophagy marker.
This conjugation is limited to the N-terminal position and exhibits moderately long deprotection times for the complete cleavage of the tris tBu) ester [ 7].
The activated aldoximes are conjugated with cysteine as a sulfur donor to produce S-alkyl-thiohydroximates; however, it is not clear whether this conjugation is enzyme-mediated.
A recent study has shown that TRIM23 mediates atypical lysine 27 (K27 -linked polyubiquitin conjugation to NEMO, which plays an important role in the NFκB pathway, and this conjugation is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses (Arimoto et al., 2010).
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