A recent study showed that mis-accumulation of SUN1 underlies the pathology of degenerative features in laminopathies, and concomitantly suggests a gain-of-function versus a loss-of-function model for the action of lamin A mutants.
This affords the possibility not only of identifying novel hits, but also for repurposing FDA approved drugs, and concomitantly suggesting possible drug side effects.
There appeared to be an additive effect on increased cell death when both inhibitors were used concomitantly, suggesting that both the PI3K/AKT/mTOR and ERK pathways are involved.
We were not able to further inhibit cytokine production by depleting p63 and IL1A concomitantly, suggesting that the majority of paracrine signaling controlled by p63 is owing to its regulation of IL1A expression.
Recent epidemiologic studies have demonstrated that the prevalence of allergies [ 1] and obesity [ 5] are both increasing concomitantly, suggesting that these diseases may be causally related [ 6], or perhaps share common risk factors such as sedentariness, inactivity [ 7], unhealthy food choices [ 8] or insufficient sleep duration [ 9].
Because resuspension of Pb from contaminated soil appears to be driving seasonal child BPb fluctuations, concomitantly, we suggest that Pb-contaminated soil in and of itself may be the primary driving mechanism of child BPb poisoning in the urban environment.
However, the intracellular concentration of ATP in the FasL-treated W3 cells rapidly decreased, whereas the concentrations of ADP and AMP concomitantly increased, suggesting that AMP was directly released from apoptotic cells.
This case suggests that these two syndromes can be concomitantly induced in some patients who are susceptible to these drugs.
This observation suggests that multiple pathways need to be activated concomitantly to achieve optimal effects on lifespan and healthspan through chemical treatments.
The colocalisation of CD147 with CD44v3-10, MCT1, MCT1 and MCT4 in this study further suggests that CD147 and CD44v3-10 concomitantlytantly regulate MDR1, MCT1 and MCT4 expression during CaP progression, associated with drug resistance.
This idea suggests another.
