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An example of this concept is provided in Fig. 4.
Support for this concept is provided by exciting recent reports.
Support for this concept is provided by preliminary preclinical investigations of the imatinib nilotinib combination.
Additional albeit indirect support for this concept is provided by examination of Ins2-Cre condeletion deletiof of AKAP150.
Further support for this concept is provided by the findings that in IGF‐1‐deficient mice, glutamate‐induced CBF changes were also significantly impaired (Fig. 3B).
Further support to this concept is provided by the evidence that, in CHO cells, subtype III co-localizes more closely with mitochondria, and thus preferentially transmits Ca2+ signals to these organelles.
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Evidence for this concept was provided by our finding that the combination of mutation and CNGs acted synergistically to enhance ras GTPase activity.
Proof of this concept was provided using mouse models wherein the locus that codes for Cdk4, one of the important gate-keepers of the mammalian cell cycle machinery, was targeted by genetic recombineering [36], [53].
A more detailed description and imaging example of this 'theranostic' concept is provided in the paragraph on neuroendocrine tumors later in this article.
A review on preclinical and clinical investigations of this therapeutic concept is provided with evaluation of the issues still to be well deliberated for an effective and safe in-human application.
A generalization of the concept was provided by the phlogiston theory, formulated in the 17th century.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com