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This compound class merits further development as anticancer clinical trial candidates.
This observation suggests that this compound class could potentially be engineered to be selective for either of the CaaX proteases.
Subsequent biological evaluation revealed that potent inhibitors of human 17beta-HSD1 can be identified in this compound class.
The emerging building blocks self-organize into new 1D chain-like POM architectures via Mn O W bridges that are rarely observed among this compound class.
We have developed a new diversity-oriented strategy leading to concise and efficient syntheses of known and new members of this compound class.
The present study focuses on rational structural modifications in this compound class with the aim of gaining more insight into its structure activity relationship (SAR).
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A structure activity relationship (SAR) study was also explored to facilitate the further development of this new compound class.
These promising results warrant further development of this novel compound class as potential potent anti-AIDS clinical trial candidates.
Viral adaptation to growth in the presence of inhibitor has been employed to compare escape rates from inhibition by this new compound class with those from a well-characterized, pathogen-directed antiviral.
Structure activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents.
In this work we extend compound class modeling by following not only the concentration of each class but also the average carbon number and variance of the carbon number distribution for each compound class.
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CEO of Professional Science Editing for Scientists @ prosciediting.com