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(Please note, this comment relates to the outcome of SMRU's 25-year collaboration not the VHX trial, as single trials are not expected to develop such a high level of research capacity).

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(P081, female, aged between 75-79) This last comment relates to a point raised by a number of participants concerning the number of professionals that they were in contact with who did not alert them to any information about benefit entitlements.

PAW editors spoke with senior writer Mark Bernstein '83 about the comment relating to this article and the book "SuperFreakonomics"; he said that he has not read the book.

We think that this comment also relates to both of the major issues that were noted and addressed in our general response above.

Panels D, E and F have been added to revised Figure 4 to address this comment, which relates to the imaging of Cy5-labeled MCP-TERT complexes over a time course of activity-dependent DNA release.

My first comment relates to the "species signature".

Another observation worth to comment relates to responders fatigue over the 7-day recording period.

My other comment relates to the discussion of a prokaryotic origin of V4R/Bet3.

We end this section with a comment relating this to earlier works and a speculation.

In this comment, issues related to the attribution of kinetic energy and drop size to rainfall simulator design are discussed, in order to shed further light on Meshesha et al.'s (2016) work, and its wider context.

This comment is related to that of Reviewer #1 and has been addressed above (the limited number of observed outcomes of competition assays can be effectively demonstrated through restriction enzyme analysis).

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