New therapeutic strategies, involving the combination of known targeted therapies with conventional cytotoxic drugs and the targeting of other components involved in angiogenesis, need to be developed.
However, the combination of known risk factors enabling to stratify patients into responders and non-responders has not been investigated so far.
Heterozygous markers of non-recurrent parents were assumed informative, through the combination of known marker phases and closely linked flanking markers, so that the recurrent or non-recurrent grand-parent of both alleles could be inferred.
The alignment was conducted on both genomic DNA sequences and a junction library including all the combinations of known junction boundaries (within a 100 kb span) annotated in the UCSC Gene database.
The thermophilic cellulases utilized in this case were a combination of known, thermal tolerant cellulases from Acidothermus cellulolyticus (E1 endoglucanase, Toopt about 80°C) and Caldicellulosirupter bescii (CelA, Toopt about 85°C) [ 7- 10].
Supersonic separators (3S) are comprised from unique combination of known physical processes, combining aero-dynamics, thermo-dynamics and fluid-dynamics to produce an innovative gas conditioning process.
This situation may have resulted from a combination of known risk factors for B19 infection such as the presence of highly viremic patients, nosocomial transmission [ 23], and transfusion-related transmission [ 24].
Several methods are proposed to represent the shape of an open boundary using linear combination of known functions.
The main goal of SPL is to support an environment where authorization policies can be expressed using a combination of known policy models (i.e., MAC, DAC, RBAC, history-based, etc).
In particular, the synchronously expressed group that includes MAs-biosynthetic genes may have the same combination of (known and unknown) cis-acting elements that are bound by the same types of transcription factors.
