Although this class of genes has not yet been fully characterized, aberrant expression of these genes has been raised as one possible explanation for the phenotypic abnormalities experienced by individuals with too few or too many X chromosomes.
Very few of this class of genes have their TSSs mapped in E. coli.
Like the lecticans, this class of genes may represent a vertebrate novelty associated with the evolution of cellular cartilage.
Accordingly, the high number of hypothetical phage-related genes that are also differentially expressed suggests some important, yet unknown, roles for this class of genes.
The importance of this class of genes in plant genomes is also demonstrated by the unusually high level of selection found at disease resistance loci [20], [21].
Furthermore, this increased rate of cryptic initiation among highly transcribed genes cannot be accounted for by differences in probe coverage among this class of genes (Figure 3D).
Enhanced expression of this class of genes could serve to bolster IL-3 effects on decay rates, or alternatively, to limit IL-3 posttranscriptional effects.
Results for this class of genes were similar those obtained by Ertel and Tozeren on the study of bimodal switch-like genes via two-component mixture analysis [77].
Finally, our finding that cytokinesis genes tend to be overexpressed in patients with poor prognosis sets forth this class of genes and their protein products as targets for antimitotic therapies.
Strikingly, the down-regulated genes in mutant D9 belonged both to the motility/adherence and chemotaxis classes in contrast to the D4 and D4-D9 mutants which up-regulated this class of genes (Table S1, Figure S3).
This is not unexpected for this class of genes, even when the array platform is within a species (rather than the type of cross-species platform used in this study).
