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Any hint of a cure will be welcomed as farmers have few weapons against this class of diseases.
In conclusion, direct analysis of LSD brain tissues and gene expression analysis performed on the blood of MLD patients revealed MTs as a novel, potential biomarker of disease progression for this class of diseases.
Perhaps the best-studied example within this class of diseases is the channelopathy cystic fibrosis (CF), which is caused by mutation of the cystic fibrosis transmembrane conductance regulator, CFTR (ABCC7).
Thus, blocking certain interactions that mediate the formation or stabilization of oligomeric toxic entities, or modulating the downstream effects of such interactions, could be an attractive treatment option for this class of diseases.
Transcripts that encode several components of the Akt/Gsk3-β signalling pathway were altered as a consequence of expression of these repeat RNAs, indicating that this pathway is a component of the neuronal response to these pathogenic RNAs and may represent an important common therapeutic target in this class of diseases.
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In this review, we will describe the limited treatment regimens currently used to alleviate primary mitochondrial disorders, as well as the potential for emerging technologies (in particular, those involving direct manipulation of the mitochondrial genome) to more decisively treat this class of disease.
For example, the extracellular region and cell adhesion molecules are not significantly perturbed in infectious diseases, consistent with the transcriptome measurement on blood for this class of disease which lacks tight cellular connection as in other tissues [27].
Certain malformed proteins, known as prions, enlist recruits and attack the brain in the class of diseases called spongiform encephalopathies, which include Creutzfeldt-Jakob in humans and scrapie and mad cow disease in animals.
Future discoveries of new non-human repeat associated defects may provide the breadth of information needed to unravel the mechanisms that underpin this class of human disease.
Since the skeletal muscle phenotype of KN1 mice is consistent with that of human metabolic myopathies, the NOS1 gene may be a novel candidate gene for this class of skeletal muscle disease.
While calcium carbonate and Alfacalcidol together comprised 33.2% of the drugs in our study, 63.6% of physicians' orders involved these two drugs, thereby positioning this class of mineral bone disease drugs as the major drug class occupying doctors' time (Table 3).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com