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Interestingly, small peptides are able to mimic the interacting partner for this class of complexes (Table 1, families 1 to 5 and references therein).
In this study we were able to confirm the cytotoxicity of two titanium salan complexes in various cell lines and showed for the first time the activity of this class of complexes in vivo.
It will be interesting to determine if the CydZ protein plays a role in providing the unique biochemical characteristics of this class of complexes.
Interaction with DNA and formation of cross-links with adjacent purine bases are considered to be the crucial steps in the antitumor activity of this class of complexes.
From the perspective of bioactivity, we observe a comparable cytotoxicity to the anti-cancer drug cisplatin, emphasising how control of the physical properties of this class of complexes can modulate cellular localization and, as a result, impact upon cell viability.
It is this class of complexes that is shown in the main diagram to go on through a long series of steps to bind peptide antigen derived from the lysosomal degradation of pathogen proteins and present them to T-helper cells.
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Two specific features of this class of complex systems are that (i) external inputs and (ii) internal sources of random fluctuations influence their dynamics.
This is also consistent with evidence from acquired aphasia, where nonfluent LH patients have difficulties with exactly this class of complex items [Tyler et al., 2002].
Metallacrowns are a member of this class of inorganic complexes.
Antibacterial activities and DNA binding affinity of this class of cadmium complexes have attracted considerable interest.
Therefore, targeting the BRCA1 RING domain protein through the disruption of the BRCA1 E3 ligase activity by this class of ruthenium complexes might be an effective approach to eradicate breast cancers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com