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Exact(25)
Structure activity relationships have been studied and binding mode of this chemical class has been proposed.
Members of this chemical class are known to interact with many receptors and transporters, particularly those of the biogenic amine class.
Representative compounds demonstrated good solubility, kinase inhibitory activity and antiproliferative activity in human tumour cells, confirming the suitability of this chemical class as a kinase-focused library.
The resulting data were analyzed using a modified forward selection linear regression procedure, thus revealing potential pharmacophoric relationships of the assessed targets within this chemical class.
Subsequently, this chemical class of DNA gyrase inhibitors was extensively investigated biologically through in vitro assays, biofilm inhibition assays, cytotoxicity, and in vivo studies.
Structure activity relationships of 33 derivatives of 5- 5-Phenyl-furan-2-ylmethylene -2-thioxo-thiazolidin-4-one have been studied and binding mode of this chemical class has been predicted.
Similar(35)
This potentiation was independent of the chemical class and the dilution of the stimuli.
The most problematic class was the chemical class multiple.
Overall, this work improves upon OPAH analytical methods and provides some considerations and strategies for OPAHs as focus continues to expand on this emerging chemical class.
This is true for all of the chemical classes assessed, including PCDDs/Fs, PCBs, organochlorine pesticides, and PBDEs.
The results obtained should prove beneficial in designing other molecules in this category of chemical class.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com