Exact(9)
Even though the timing of this change remains speculative, the pattern of AGD increase during infancy suggests that a significant component of the remaining perineal growth is likely to occur at puberty along with growth of the external genitalia.
We report a coding sequence change in several patients and describe why the pathogenic role of this change remains unclear.
Disseminated dormant cancer cells can resume growth and eventually form overt metastases, but the underlying molecular mechanism responsible for this change remains obscure.
The molecular basis for this change remains unknown.
We observed a reduction in SV after T2, although the mechanism behind this change remains unclear.
We have previously reported that GRP78 promotes the invasion of hepatocellular carcinoma although the mechanism underlying this change remains uncertain.
Similar(51)
Although the pathogenesis of this phenotypic change remains uncertain, available data suggest that this may involve the acquisition of a combination of increased proliferative potential and resistance to apoptosis [ 3].
Analysis of the late increase indicated that the amplitude of this increase is concentration dependent, although the biologic relevance of this small change remains to be determined.
"I don't think the effects of pollution on bone density is a direct threat to the persistence of polar bears as a species at this time climate change remains the main threat to the species," agreed Derocher.
Interestingly, mimicking phosphorylation at S184 site by a glutamate substitution (i.e. S→E) in the C-terminal tail of Bax results in another type of conformational change that represents a mobility-shift (Fig. 1A) but the functional significance of this conformational change remains unclear.
While the molecular explanation for this conformation change remains elusive, the fact that the helix is formed after flavin reduction is certainly suggestive of a key detail in the RebC catalytic cycle: substrate must bind before flavin reduction.
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