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This case-definition has previously been used [ 13, 14].
This case definition has been shown to have excellent sensitivity (86%) and specificity (97%) [ 25].
The case definition has been validated in a previous study.
The case definition has been previously described (5, 10 ).
The case definition had to take into account this particularity.
In our study, we would have identified only secondary cases if a probable case definition had been used because IgG is initially absent in primary dengue.
The suspected H5N1 case definition had 2 components: the hospitalized case definition included severe respiratory illness and recent travel to an H5N1-affected country; and the ambulatory case definition included acute respiratory illness, contact with domestic poultry or a known or suspected H5N1 case-patient, and recent travel to an H5N1-affected country (6 ).
Case finding started in clinical laboratories, and case definitions have included isolation of an organism as part of the case definition (e.g., invasive pneumococcal disease isolation of S. pneumoniae from a normally sterile body site).
None of the patients reported to CDC had touched poultry, and 48% of persons with cases that met the CDC suspected H5N1 case definition had not been <1 m of birds during travel.
Case definitions have been established.
Case definitions have been described (8 ).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com