I can't think that can necessarily be true.
"Thus this publication can necessarily be only one step toward a greater understanding of 'disappearances,' one step in the continuing search for effective remedies".
It is not implied that any organisms carrying this ancient pathway can necessarily polymerize p-coumaryl alcohol (H monolignol) to form H lignin or even synthesize the more complex G and S monolignols, but they are likely able to synthesize at least p-coumaryl alcohol.
This definition of "meaningfulness" can necessarily be adapted to the specific use case, though could encompass criteria such as economic factors, preservation of certain chemical structure elements across the route, minimisation of process condition changes between synthesis steps, or the consideration of different sustainability criteria.
However, I do not think this means that we can necessarily extrapolate to other features of eukaryotes, such that 'protoeukaryotes' become the ancestral state.
Recent large trials, originally presented at the ADA Scientific Sessions in 2008, have failed to demonstrate that intensive glycemic control strategies can necessarily reduce this burden (15– 15).
Libertine's comment was given to us in good faith, and we have no reason to doubt the club's intentions, but sadly, this isn't an issue that can necessarily be disproven with data.
This is not to say that we can necessarily assume that data may be combined without due care.
"Since then, work no longer seems like a place you can necessarily count on".
Not that you can necessarily tell, until the very last moment, which is which.
