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Superposition of Parkin with RING-E2 complex structures revealed significant steric clashes of E2 with the Parkin linker helix that connects IBR and RING2 (red in Figure 4B and E), as this binds RING1 across its E2 and Ub binding sites.
All sequenced eukaryotes express at least one CDK that contains the cyclin-binding PSTAIRE motif in subdomain III of the catalytic domain; when this binds cyclin, a conformational change is induced which enhances the ability of the kinase to bind ATP.
This binds more than just two people".
"This binds the politics much better" than a smaller loan paid up front, he said.
It could be argued that at least this binds wealthier families into a universal welfare system.
This binds the liposome to the toxin, and the liposome-toxin-antibody combinations stay put while everything else is washed away.
Similar(38)
This bound is strained frequently.
"It's put itself in this bind".
In effect, this bound the hands of the new administration.
One week ago, Andrew Sullivan, a contributor to The New York Times Magazine and The New Republic, found himself in this bind.
His only consolation, he said, was that he wasn't the only one in this bind.
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CEO of Professional Science Editing for Scientists @ prosciediting.com