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Seleno-containing compounds react more rapidly with some oxidants than their sulfur analogues, owing to the low p Ka of the Se–H bond (5.2 [ 15]) which results in this being predominantly ionized at physiological pH values (cf. a p Ka of ~8.4 for free cysteine [ 16]), the protein environment of these residues and the greater nucleophilicity of the selenium atom [ 17].
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