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For instance, in the other recent study on this topic, Dr Lisa Croen and colleagues found this attributable risk to be less than 2.5% in their Northern California population.
The limitations of this study include the absence of a control group and the small cohort of patients but this attributable to the restriction in the inclusion criteria to preserve group homogeneity.
This attributable fraction is 27.9 (95 % CI 9.6 42.5%%) among the sub-group of inactive individuals.
This attributable risk was calculated as the adjusted rate ratio (obtained from the Cox proportional hazards regression model) minus 1, divided by the adjusted rate ratio, multiplied by 100.
This attributable proportion was then extrapolated to US rates of all-cause acute gastroenteritis from 3 FoodNet population surveys, hospitalizations from 3 databases (NHDS, the Healthcare Cost and Utilization Project Nationwide Inpatient Sample, and NAMCS/NHAMCS), and deaths from the multiple cause-of-death mortality database in the National Vital Statistics System.
Our finding that depressive symptoms are significantly associated with virological response independent of pharmacy refill adherence deserves further investigation: is this attributable to a physiological or behavioural mechanism or does it reflect limitations of our method used to assess medication adherence?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com