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The authors proposed that the E282Q is associated with PA but this association needs to be confirmed in larger studies in a population in which the frequency of E282Q carriers is well-known.
Antibiotic treatment of asymptomatic bacteriuria is associated with a decrease in the incidence of preterm delivery or low birth weight, but the methodological quality of the studies means any conclusion about the strength of this association needs to be drawn cautiously.
Of note, of the 5/17 patients with either partial response (PR) or stable disease (SD), three of the five had >50% PD-L1 + CTCs, while the other two had no PD-L1 positive CTCs; however, given the small number of patients with response, this association needs to be analyzed in a larger cohort to determine the overall impact of an increased fraction of PD-L1 + CTCs.
However, this association needs a numerical generation of the chaotic behavior since the XBee protocol is based on digital communications.
For keratinocytes, no relation between TSLP secretion and TRPV1-mediated Ca2+ influx has been demonstrated, and this association needs to be investigated.
This association needs to be further studied prospectively to determine causality, specifically exploring timing of AKI onset in relation to nephrotoxin exposure in critically ill pediatric patients.
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Accordingly, studies investigating this association need to encompass an observational period of several decades.
This association need to be evaluated in larger series of BRCA1 mutation carriers.
Adipose tissue is considered a metabolic organ, and the underlying mechanisms for this association need to be investigated further.
Although the observations noted above support an association between EBV, or the host's immune response to it, and RA, this association need not be causative.
The pathophysiology mechanisms and direction of this association need further study using a purposively designed prospective or intervention study in samples at high risk for diabetes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com