Exact(2)
We used primaquine (PQ) to establish this assay model, because PQ is the only licensed drug known to clear all Pv hepatocyte stages, including hypnozoites, and the effect of PQ on Pv hepatocyte stage development in vitro has not previously been reported.
We used primaquine (PQ) to establish this assay model, because PQ is the only licensed drug known to have an effect on hepatocyte stage development including clearance of hypnozoites and secondly, unlike with P. berghei [21], P. cynomolgi and P. knowlesi [22], the effect of PQ has not been evaluated on Pv hepatocyte stage development in vitro.
Similar(58)
This assay models the later stages in successful metastasis, without the formation of a primary tumour site [ 17].
To assess the variability in the assay model several different lots of oocysts should also be measured.
Taken together, this ex vivo cardiac assay model offers a powerful tool for evaluating several dimensions of potential cardiovascular toxicity of lead compounds.
Despite the fact that MIP has been found to be highly resistant against isoniazid (INH) in an in vitro assay model, in this study the microbe was highly susceptible to this standard anti-TB drug.
In this study we present a novel, purified functional assay model for C5 convertases in which we mimic the natural orientation and density of C3b molecules on bead surfaces.
This was confirmed ex vivo using an aortic ring assay model of angiogenesis, in which rings from WT and EC JAM-C-KO animals exhibited a similar angiogenic response (Fig. 4 F, G).
The assay model can be expanded for all fissile materials.
This is a direct observation on the efficacy of the compound against MIP tested in an in vivo assay model.
In the in vivo assay, model control animals displayed a decrease in immunity activities.
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