The analysed CpGs are primarily located in proximal promoter regions (and preferentially inside CGIs) and the array encompasses probes with an average coverage of 1.9 CpG sites per promoter.
I'm disappointed as a critic, hankering for a denser, more chronological array — encompassing the more than five hundred works she has made since 1977 — to enable a fully informed career analysis.
The tiling array encompassed SCL and all of its known regulatory sequences, and the neighbouring genes MAP17 (PDZK1IP1) and SIL (STIL), and the 5' end of the housekeeping KCY (CMPK, UCK) gene, all of which are expressed during haematopoiesis [14].
Enriched fragments were hybridised against total input DNA on a Nimblegen 385k array, encompassing known regions of genetic susceptibility to T2D (regions identified from previous locus and genome-wide association analyses; monogenic T2D and obesity genes and related disorders (as of 2008) (see Supplementary Table S1 for full list).
The array encompassed 56 oligonucleotides targeting 123 reference ORFs, whose expression pattern has been established previously.
The Agilent rat whole genome custom array encompassed 41,129 different oligonucleotide probes according to the latest annotation of the rat genome.
Priority was given to well-referenced studies, employing the Affymetrix ATH1 GeneChip array, encompassing the broadest possible spectrum of plant defense responses upon pathogen infections or pathogen-mimicking stimuli treatment (Additional file 2: Supporting methods).
Using a custom array encompassing 2 Mb around the LMNB1 gene, we were able to accurately determine all duplication sizes, finding a total of 16 unique rearrangements (Fig. 1A and B, Table 1).
In order to develop a resource for rapid and cost efficient analysis of genetic divergence between freshwater and marine sticklebacks, we generated a low-density SNP (Single Nucleotide Polymorphism) array encompassing markers of chromosome regions under putative directional selection, along with neutral markers for background.
