There was a significant increase in new onset supraventricular arrythmias, with over 50% of patients with elevated heart rate developing new-onset atrial fibrillation, and this appeared to precede the cardiac events.
Within the panel of homeostatic cytokines, IL-7 appears to be reduced in RA [ 78]; however, IL-15 and IL-21 are increased [ 79, 80], and this increase appears to precede disease development.
It is important to check for the exacerbation of DM symptoms because this symptom sometimes appears to precede cancer relapse in the follow-up of patients with colorectal cancer and DM.
Moreover, it was demonstrated for the first time that micromolar concentrations of CQ partially permeabilized the parasite's digestive vacuole (DV) membrane and that this important upstream event appears to precede mitochondrial dysfunction.
Among a clinical sample of military personnel, increased anger and depression statistically mediated the association of mild TBI and suicide risk, and anger appears to precede depression in this pathway.
Since increased CVR appears to precede RA onset (Young et al., 2007), this model offers an ideal opportunity to identify the very earliest pathological changes within the vasculature that could subsequently contribute to full-blown CVD.
Increased MINT locus methylation appears to precede MSI and may have utility in defining clinical pathology in the absence of features of malignant invasive tumors.
Due to the collapse of ψm as a result of the leakiness of the inner mitochondrial membrane, cytochrome c is released into the cytosol, which appears to precede the activation of caspase-9 and caspase-3.
Thus, the point of commitment to initiate stalk morphogenesis appears to precede that of initiation of chromosomal replication.
In these experiments, cell viability began to decrease rapidly after 8 h, so the decline in nad5 and atp6 mRNAs appears to precede cell killing.
