RNase R treatment largely removes the false positive results, however, this strategy also impairs the quantitative feature of the circRNAs, especially the co-expression correlation between circRNAs and their parent genes.
This mutation also impairs TNRC6s silencing activity.
According to this hypothesis, it also impairs the ability of POT1-TPP1 to recruit or activate telomerase in cell types with high proliferation rates that express functional telomerase (such as cells of the hematopoietic system).
Expressing this polyQ protein also impairs proliferation of aneuploid yeast strains more than that of euploid controls, indicating that expression of a hard-to-fold protein affects the fitness of aneuploid cells (Oromendia et al., 2012).
The fact that Glu16 also impairs HOIP activity also suggests the functionality of this side chain in assembly reactions.
Hyperglycemia also impairs SF and may have been a factor in this sample (mean A1C >8%) (11).
Blocking the effects of adrenalin with a beta-blocker also impairs the emotional memory (I've even done experiments of this sort myself).
Lack of sleep also impairs performance.
Binge drinking also impairs sperm production.
So does diabetes, which also impairs circulation.
