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However, the theoretical potential to perform the proposed adjustment suggests that this method possibly might provide a quantitatively or qualitatively accurate estimate of an unconfounded treatment effect in circumstances in which instrumental variable analysis may not be possible.
Although the age-adjusted findings in our two cohorts are somewhat more consistent with previous positive results, multivariate adjustment suggests considerable confounding in this relation.
The mechanism behind this association is not clear but multivariate adjustment suggests that the beneficial effects of HT are not explained by other behavioral, aging- and health-related variables.
While much of this ruminating seems pro forma (Oh, come on, Mr. Paganini, couldn't you play us one more tune?), an exceptional story called "Keller's Adjustment" suggests a good cause for the hit man's malaise, something just about every reader can share — even with a sociopath.
Multivariate adjustment suggests that the association of HT with improved sleep is independent of these factors.
This difference in case-mix does confound the interpretation of outcomes between the two cohorts, but statistical adjustment suggests a worse outcome for strokes admitted after the pathway was introduced.
The persistent association between SGA and socio-economic disadvantage, and between SGA infants born to Aboriginal mothers, after multivariable adjustment, suggests the existence of some unmeasured risk factors for which socio-economic status and Aboriginality are proxies.
The reduction in differentially methylated sites after cell proportion adjustment suggests that the present statistical analysis has the ability to lower false-positive detections of sex-differential DNA methylation sites.
However, our finding of a significant association of adiponectin with incident diabetes after HDL adjustment suggests that these two variables may be linked through mechanisms that are not directly related to diabetes pathogenesis.
The fact that the temperature effect is robust to these adjustments suggests that air pollutants are not solely responsible for the higher risk during colder weather.
However, this significant association disappeared after adjustment, suggesting that the effect of body image was mediated by baseline BMI z-score.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com