First, monitoring should be performed as frequently as disease activity necessitates, namely more frequently (such as every 1 3 months) with active disease and less frequently (such as every 6 12 months) once the treatment target has been stabilised.
H2-oxidative endo-hydrogenase activity necessitates that H+ ions be membrane-translocated else deplete the cell membrane proton-motive force.
Thus, while PEGylation can successfully reduce the enzyme's immunoreactivity, maintaining a homogenous enzyme composition with high catalytic activity necessitates a more controlled PEG-conjugation strategy.
In addition, live cell imaging of enzymatic activity necessitates a well-defined start point.
The intense outcome associated with adolescent sexual activity necessitates the search for a positive way out and thus, the main objective of this study.
Our results support recommendations that effective In vitro suppression of endogenous protein-phosphatase activity necessitates the inclusion of a wide assortment of protein-phosphatase inhibitors (e.g. NaF, MoO4−, VO3−, PPi and microcystin-LR) in extraction and purification buffers [ 34].
TALENs and ZFNs incorporate the nuclease domain of the type IIS restriction enzyme FokI, and the requirement of the FokI nuclease domain to dimerize for activity necessitates the design, construction, and delivery of TALENs (or ZFNs) in pairs targeting opposing sites in a head-to-head orientation flanking the target for cleavage.
This observation suggests that neither increased adipogenic gene expression nor increased PPARγ protein activity necessitate lipid droplet accumulation.
The observation that receptors can demonstrate spontaneous activity necessitated elements of ion two-state theory to be incorporated into receptor theory.
However, the development of adrenergic hyposensitivity and the subsequent loss of catecholamine pressor activity necessitate the search for other options.
Communication of test results is a complex yet core primary care activity necessitating flexibility by both patients and staff.
