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Because MVAΔudg was blocked at the E→L transition during infection of non-complementing cells in culture, we determined whether this abrogated in vivo CD8+ T cell responses directed against viral late gene products following immunization of mice.
As expected, this abrogated c-Mos mRNA polyadenylation and translation in oocytes exposed to progesterone.
This abrogated heme binding and inactivated the enzyme, suggesting that the conserved H338 is indeed the proximal histidine of TfuDyP and other DyP-type peroxidases.
This abrogated DNA repair by non-homologous end joining and led to a slower disappearance of foci, as DNA damage can be repaired only by homologous recombination in the presence of this drug.
This abrogated the pro-senescence effect of Col1a1 r/r collagen (P = 0.003, Fig. 5E).
The inhibition of P38 resulted in multimeric complexes of HSP27 and this abrogated the interaction between HSP27 and DAXX.
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53BP1 binds to lamins A/C via its Tudor domain, and this is abrogated by DNA damage.
Whereas an A>T substitution at position 7 permitted binding, an A>C substitution at this position abrogated DNA binding (Fig. 2E, lanes 1 3).
Therefore, this provided a ready mechanism for the abrogated apoptosis.
We reasoned that if channel-activity has no effect on cell spreading, then an alternative possibility is that T154A and Y17S mutations cause a secondary defect in the Cx43 molecule other than the well-known channel disruption phenotype and this secondary defect may have contributed to the abrogated cell spreading.
In fact Allegra and colleagues showed that EPO treatment lowered BMI, LDL, and apolipoprotein B significantly if the patients did not increase their food intake, while this effect was abrogated if food intake was increased [3].
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CEO of Professional Science Editing for Scientists @ prosciediting.com