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This a grievous blow.
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This was a grievous error.
This is a grievous, self-inflicted wound.
Many of us will feel this is a grievous omission.
This is a grievous lapse that is not in the country's interest.
In a novel of slightly less than 250 pages, this is a grievous narrative misappropriation.
The group argued that this was a grievous scientific error and cited evidence that melancholia was qualitatively different from other forms of depression.
"The precedent set by this decision, if upheld, would increase uncertainty significantly with a consequent adverse effect on foreign investment in Europe, making this decision a grievous self-inflicted wound for the European Union and its citizens".
In a literature so concerned with social as well as technical innovation, with the effects of change – incremental as well as abrupt – on individual humans and humanity as whole, this is a grievous, fundamentally hubristic mistake to commit.
"When a member of the colony, a worker drone, is killed, this is a grievous loss for the hive.
This was considered a grievous violation of turf.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com