Exact(1)
A third vaccinia virus, expressing the N-terminal third of gp150 with a GPI anchor, has been described [21].
Similar(59)
Vaccination, invented in 1796, let doctors infect patients with a kindred but usually benign virus (cowpox at first, vaccinia later) that gave smallpox immunity.
With the first vaccinia OI (Pexa-Vec, thymidine kinase-inactivated vaccinia expressing Granulocyte-colony stimulating factor [GM-CSF]) now in advanced-stage clinical trials, it has become more important than ever to understand the complimentary MOA that contributes to tumor destruction and control in patients.
According to a study of 11.8 million Americans in the 1960's, for every 100,000 people vaccinated for the first time, vaccinia spread to two to six others who had not been vaccinated.
We explored the duration of immune responses and the effect of a late third HIV-modified vaccinia virus Ankara (MVA) boost in HIV-DNA primed and HIV-MVA boosted Tanzanian volunteers.
For every 100,000 people vaccinated for the first time, the study found, vaccinia spread by close contact to two to six others who had not been vaccinated.
To describe the presentation and management of the first identified case of ocular vaccinia infection associated with the current smallpox vaccination program.
First et al. evaluated vaccinia virus in a full-scale chamber under steady-state conditions at 50% RH and reported similar results to our summer conditions.[9] The additional effective ventilation due to upper-room UVC, even in the summer, ranged between 18 and 71 ACH, rates in excess of what is usually achieved in hospital rooms designed for airborne precautions (approximately 12 ACH) [12].
Second, we used a recombinant Vaccinia virus (VACV) system expressing EBOV GP and demonstrated that this vector protected guinea pigs from EBOV hemorrhagic fever (13).
VH1 has at least two important functions in the Vaccinia virus lifecycle: first, it dephosphorylates two-virion membrane-associated factors A17 [ 149] and A14 [ 150], in vivo.
Since the discovery of the first DSP, VH1, encoded by Vaccinia virus, 61 VH1-like DSPs have been identified in all kingdoms of life.
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