For the 32 patients who progressed and the first site of progression could be assessed, 10 patients first progressed locally (i.e., progression or a new lesion in the pancreas), 27 patients first progressed systemically, and five patients first progressed both locally and systemically.
While biotechnologies for drugs first progressed through chemistry, until relatively recently food technologies evolved by mechanisation, the gradual replacement of human hands by machines.
Of the 11 patients in FSGS group, every one of them presenting with nephrotic syndrome, one-third progressed to ESRD during a mean of 2.9 years of follow-up.
Over a decade, one-third of those with IFG or IGT became normal glucose tolerant, one-third progressed to diabetes, and one-third continued to have pre-diabetes, although the frequency of progression appears to be worsening in recent studies (57).
For patients with transition directly from CG0 to CG2, it has been assumed, for computational reasons, that the patient first progresses to CG1, but instantaneously progresses further to CG2 without producing person-time in CG1.
Third, progress curves in a 96-well plate format were employed to determine apparent kcat/ KM values.
About one-third of the patients achieve spontaneous remission, another third remain active with fluctuating proteinuria, and the remaining third progress to end-stage renal disease (ESRD) [ 11].
As the third set progressed, her unforced errors grew and her patience thinned.
Despite the medical timeout that followed, the second set progressed in a similar vein to the first.
Unfortunately, as the first episode progressed the feeling of excitement I had when I first started watching slowly wore off.
