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The third major problem with EMD is its decomposition sequence.
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Galloway had solved the first major problem in developing his drug.
The second major problem is that human memory just isn't reliable.
The second major problem with Move is that it can be finicky to use.
The second major problem with the approach of the Bush administration is that it endangers our political traditions and our commitment to liberty, and further damages America's legitimacy in the eyes of others.
The State Health Department fined Beth Israel $14,000 and ordered it to improve its monitoring of doctors as a result of Dr. Zarkin's actions, the second major problem in the hospital's obstetrics and gynecology department in two years.
The impasse is the first major problem for Mr. Assad, a mild-mannered 34-year-old eye doctor and computer enthusiast who inherited leadership of Syria, along with the rank of lieutenant general and commander of the army, upon the death in June of his father, Hafez al-Assad, who had run both countries with ruthless skill.
This wasn't an easy balance to maintain, and the first major problem arose when State Department officials learned that if Mubarak stepped down immediately, the Egyptian constitution would require a Presidential election in sixty days, long before any of the moderate parties could get organized.
In eight clear-headed minutes I reach the deserted Savoleyres ridge, faced with the first major problem of the week: deciding where to go within the Four Valley's 400km of groomers and the endless off-piste, criss-crossed by nearly 100 lifts.
So the second major problem this initiative faces is trust.
"The first major problem we wanted to solve was the battery mobility problem.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com