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Twenty patients underwent a third course of therapy.
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Interestingly, the one subject that underwent a second cycle of therapy after an 9-day interruption, rebounded to approximately the same 20% increase in private mutations that was observed during his first course of therapy.
All patients received tamoxifen as part of their first course of therapy.
The remaining 26 patients experienced relapses that required a second course of therapy (Table 2).
Fifth, hormone users, particularly if they were healthier, might have received additional treatments beyond their first course of therapy.
The vast majority of patients (20/22; 91%) reached disease-free status at 2 weeks after the first course of therapy.
A total of 178 patients received a second course of therapy with an alternative anti-TNF drug.
NCCC-SEER provided a summary of curative treatment information given as the first course of therapy following diagnosis.
The SEER programme routinely collects information regarding certain anti-cancer therapies (i.e. surgery, radiation therapy) occurring within 4 months of diagnosis (first course of therapy).
Using these criteria, PASI-75 response rates for IV alefacept increased from 29% during the first course of therapy (n=521) to 54% during course 5 (n=39).
Three patients were unable to complete the first course of therapy because of rapid disease progression; one of them died of a progressing haemorrhagic brain metastasis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com