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"We need to understand that this new devices business will be a very, very new startup and it has very different kinds of needs in terms of management as well… Only a very thin organization will be needed in the beginning," he added.
The researchers did not contact the practices directly, but did so via the Additional Information Services (AIS), which is part of the THIN organization.
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Mr. McCain's colleagues on Capitol Hill, disaffected for years by his maverick stances on tax cuts, spending, campaign finance and immigration, have groused about his thin campaign organization and unfocused message.
It has been suggested that interaction with myosin is critical for α-actin thin filament organization.
Similarly, inhibiting myosin ATPase with BTS also resulted in disruption of thick and thin filament organization.
To test whether thin filament organization was affected in smyhc1 knockdown embryos, we examined thin filaments in smyhc1ATG-MO injected embryos by immunostaining with anti-α-actin antibody.
Similarly, treating zebrafish embryos with BTS disrupted thick and thin filament organization, with little effect on the M- and Z-lines.
However, thick and thin filament organization was significantly disrupted in both slow and fast muscles of BTS-treated embryos (Fig. 6F, H, J, L).
It should be noted that inhibiting myosin function by BTS exhibited a specific effect on the thick and thin filament organization without much effect on the M- and Z-lines.
In contrast, incubation with DMSO, used in making BTS solution, had no effect on thick and thin filament organization (Fig. 6E, G, I, K), confirming that the muscle defects were BTS-specific.
(A ) Exon (thick regions) and intron (thin regions) organization of the ptrn-1 locus.
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