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The outermost layer rests on a thickened basement membrane, the dermis.
Individuals with diabetes (but without cystic fibrosis) have lung parenchymal histological changes including thickened basement membrane, fibrosis, and septal obliteration (26), suggesting a direct deleterious effect of hyperglycemia.
In the 5α-R2 deficiency patient's testis, haematoxylin-eosin staining revealed heterogeneous seminiferous tubules, surrounded by few peritubular myoid cells and a thickened basement membrane.
Tubules were limited by a thickened basement membrane and contained mostly Sertoli cells and a few germ cells arrested at the spermatocyte stage (Fig. 2).
Atrophic areas were defined as those containing any combination of globally sclerosed glomeruli, shrunken tubules with thickened basement membranes, interstitial fibrosis, cysts, and occluded vessels.
The most frequent renal lesions were interstitial nephritis with eosinophilic infiltrates and tubular atrophy and glomerular lesions (mesangial expansion, hypercellularity and thickened basement membrane).
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PIG is characterized by specific changes to the thickened glomerular basement membrane (GBM), including microspheres, microtubular structures, and podocytic infolding.
The glomerular changes are characterized by specific lesions of the thickened glomerular basement membrane (GBM) including microspheres, microtubular structures, and podocytic infolding [ 1].
In a series of 14 patients, Chusid et al. [ 1] found two cases with glomerular mesangial expansion and thickened glomerular basement membrane and one case with eosinophilic infiltrates in the kidney.
Previous studies using human placental tissues or a rodent model of ICP have revealed several morphological abnormalities in ICP placentas, including focally thickened amniotic basement membranes, chorionic villi that are small for gestational age, crowding and congestion of the villi, and an increased number of syncytial knots [ 12, 13].
Residues of non-thickened tubular basement membranes neighboured some intact tubules.
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