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We postulated that invertebrates lack laforin because they do not synthesize an insoluble glucan as an energy source (as do the protozoans that contain laforin) and they do not inhibit insoluble glucan accumulation (as seen with vertebrates inhibiting LBs).
Perhexiline, amiodarone and rottlerin inhibited mTORC1 signaling much more slowly than rapamycin, which caused complete inhibition within 5 min (not shown), suggesting that they do not inhibit mTORC1 directly.
Selective serotonin reuptake inhibitors, or S.S.R.I.'s, enhance the neurotransmitter serotonin; they do not inhibit it.
Indeed, they do not inhibit intestinal and placental alkaline phosphatases.
In contrast to the other tissues, they do not inhibit Pgp activity in term human placentae.
In this manner, toxic proteins can still be produced as far as they do not inhibit ATP production and protein synthesis.
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They don't inhibit movement, or have any real practical use.
Two world wars, Nazi attacks on all but the most cringing art, a lonely decade in Amsterdam followed by emigration to the United States, these external events certainly impinged on his work, but they did not inhibit it.
They did not inhibit but could promote the proliferation of ECs within 90 days.
Therefore, new synthesized FGABAs are structural but not functional analogs of GABA (because they did not inhibit synaptosomal [3H]GABA uptake).
High selectivity of these compounds toward Hsp90 was evident given that they did not inhibit a panel of 34 kinases at 10 μM.
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