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When introduced together in the absence of the other mutations, the 3'NTR mutations were not fully compensatory, but they did confer a low level of replication, with sporadic detection of viremia (≤2.5×104 ge/mL) at multiple time points, (T16457 and T16463, Fig. 4E).
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It is not fully understood how these mutations contribute to the development of tumours, but they do confer a modest increase in catalytic activity [ 12, 13], are capable of inducing transformation of cultured cells [ 14– 16] and are capable of inducing tumours in vivo [ 17, 18].
The association between genotypic mutations and the phenotypic susceptibility to antiretroviral drugs is complex, so although T215 revertants are considered by the Stanford HIVdb algorithm to result in only low level resistance to nucleos(t)ide reverse transcriptase inhibitors, they do confer a low genetic barrier to the development of high level resistance to this drug class.
But aides to the two men did confer beforehand.
Management did confer with the jockeys, who did not voice any serious objections to riding in the intense heat.
However, several types of malignant neoplasms did confer significant elevations in risk for neonatal death.
Interestingly, MSN2 overexpression did confer rapamycin sensitivity (Figure 7A).
Living consistently alone did confer increased odds for caseness.
The addition of SY to the EtOH liquid diet did confer some ameliorative effects upon the developing fetal rat brain.
Passenger mutations are best defined as those that do not confer a selective growth advantage to the cells in which they occur, while driver mutations are those which do confer a growth advantage.
Owning the place does confer some privilege, though.
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