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The activity of genes that are not part of this control mechanism can be regulated if, for example, they are downstream of the Notch signalling pathway.
They are downstream genes in the tryptophan metabolic pathway, possibly associated with auxin/IAA synthesis in response to water deficit.
In all six cases, expression is reduced in spt, suggesting that they are downstream targets of tbx16.
Wetlands are landscape sinks for nutrients and propagules, making them especially vulnerable to plant invasions as they are downstream from most disturbances (Zedler and Kercher 2004).
The encoded proteins cyclin D1 and p21Cip1 were downregulated and upregulated, respectively, in sFRP1-expressing tumors, suggesting that they are downstream mediators of WNT signaling.
Furthermore, we analyzed both IRF-1 and IRF-9 on a transcriptional level by real-time quantitative PCR, because they are downstream targets of the Stat1 signaling cascade, without finding significant differences (data not shown).
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Rather they may be downstream of pathways regulated by miRNAs or other regulatory activities in the cell.
Unlike the genes identified by molecular genetic approaches, only one of these genes encodes a known transcription factor, suggesting they may be downstream effectors of Wnt signaling in the worm.
We describe here the first report of a high-throughput screening of expression profiles of miRNAs regulated by Nanog in postnatal NSCs and identify a number of miRNAs that are modulated following increased or decreased expression of this transcription factor, suggesting that they might be downstream effectors of Nanog.
Interestingly, MYBCORE, the key cis-regulatory element for binding PA synthesis regulating Myb transcription factors [ 40], was found in all of them, suggesting that they could all be downstream targets of the putative Tc-MYBPA.
Nutrient spiraling is another concept invoked to explain the cycling of nutrients while they are carried downstream.
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CEO of Professional Science Editing for Scientists @ prosciediting.com