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These well characterized compounds were then tested for anticancer potential by determining their IC50 values and antiproliferative activity on HCT116, MCF-7 and HeLa cancer cell lines.
Using manual annotation we connected these well characterized maize loci to gene models created by maizesequence.org, the group that recently published a sequence of the maize genome.
These well characterized cells are notable because of their actin dependent, highly polarized tip growth and the ease with which they are transformed.
In this scenario, our observations imply that the key cis-regulatory sequences essential for SHM targeting reside in non-coding regions of the Igκ locus outside these well characterized transcriptional control elements.
These well characterized compounds were therefore utilized in the initial tests of the sensor.
In contrast to these well characterized genomes, only three enteropneust genomes are known from Hemichordata.
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For this study, we chose to limit our validation to upstream gene promoters, as these are well characterized for their effects on silencing gene expression [44].
These are well characterized and as mentioned above, include amongst others H3K27me3, macroH2A incorporation, H2Aub and DNA methylation.
In addition to these relatively well characterized antigen targets, a number of potential new targets are being studied that may have relevance to breast cancer immunotherapy.
It would be particularly interesting to make GRY53/7HC analogues of H. pylori and B. anthracis GRs, as these have well characterized allosteric pockets remote from the active site.
These values clearly show that these properties are well characterized in the vectorial representation used.
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