Sentence examples for these two substitutions from inspiring English sources
These two substitutions enhanced the affinity of p53 for specific DNA yet, counterintuitively, decreased the residency time of p53 on DNA.
Thus, we hypothesize that the reduced enzyme activity reported by Takahashi et al.[4] resulting from either of these two substitutions results from a more weakly bound cofactor.
As these α-gliadins genes encode a shorter version of the immunodominant 33-mer in which the DQ2-Glia-α-2 epitope is already non-functional, and contain a version of the DQ8-Glia-α1 epitope that has no T cell stimulatory properties, these two substitutions would completely remove toxicity in proteins encoded by such modified genes.
It has been shown, however, that two other mutations in the NA gene (V234M and R222Q) can provide a compensatory effect by increasing NA surface expression, and that these two substitutions indeed occurred in the evolution of the H1N1 seasonal strain between 1999 and 2007 [24].
Hence, these two substitutions might explain why CDS does not prefer IPP as a substrate.
These two substitutions may have greatest impact on the binding properties of the enzymes.
These three substitutions typically result in an about 10 100-fold increase in human IgG10 100-foldo human FcγRincrease16).
These nine substitutions below get the job done, and then some.
Among the clade 2B-2 vinuses in the 2008 2009 season, all of them harbored these five substitutions comparing to the wild-type clade 2B-1 viruses.
Four of these ten substitutions were localised on the virion surface, with two (S47A and S88G) increasing the surface hydrophobicity of "ricinus" strains and two (D178E and D277E) being conserved (Fig. 2B).
Sequence alignments of response regulators homologous to BvgA as well as the X-ray structure of one such protein indicate that these three substitutions are at non-conserved positions in the superfamily (not shown).
