These two specificities allow osteoclasts to invade bone and create a resorption pit, which can latter be filled up by osteoblasts synthesizing new bone matrix.
Regarding the issue of race and coexistence of these two specificities in SSc, the prevalence was reported as 2% in Caucasian, 13% in African American, and 16% in Japanese in another U.S. cohort [ 2].
Satisfying the two specificities by a binary combination of Flp variants, while necessary, may not be sufficient to elicit recombination.
The two specificity categories are presented in Table 2a and distributed over the three sensitivity categories.
It may be difficult to discern intranidal arterial aneurysms from intranidal venous ectasias (Fig. 4), which is why these two angioarchitectural specificities are grouped as one entity in most series.
In six of these seven studies, specificity rates could not be calculated as the reference tests indicated all patients had nigrostriatal cell loss.
As in crustaceans, these three PI specificity types are present in most insect orders.
However, our sample has two specificities.
Regarding these two subgroups, sensitivity, specificity, NPV, and PPV were calculated using ER, gRE, LGE, and the cutoff values derived from receiver operating characteristic (ROC) analysis for the ER and gRE values (Fig. 3).
Interestingly, many PDZ domains with these three distinct specificities contained identical amino acids at positions that directly contact position 0 but differed in the loop that does not contact position 0. Computational modeling of the selected PDZ domains shows how slight conformational changes in the loop region propagate to the binding site and result in different binding specificities.
