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All these targets show oxidoreductase activity.
These results suggested that, during early stages, these targets show a high possibility of being regulated by miRNAs in cases of nerve allotransplantation with FK506 immunosuppression, although the possibility of false-positive prediction from the prediction algorithm always exists.
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A close examination of these targets shows various reasons for the ranking failure.
These targets showed similar amplification between H3K4me3 and mock ChIP samples as expected.
Some of these targets showed similar inductions in S. aureus during phagocytosis by neutrophils or when surviving within epithelial and phagocytic cells [ 54, 55].
Mapping analysis of these targets showed elevated binding of Mbnl2 in the vicinity of alternatively spliced exons in Mbnl1 KO mice compared to WT (Fig 7C).
All these targets showed induced expression levels in MSDACs (compared to parental SH-SY5Y) and manifold of metastatic tumors (compared with non-metastatic xenograft) as examined with immunoblotting.
When comparing these targets shown in the network to our previous mRNA microarray data [ 9], however, we found that only TLK targeted by miR-205 showed significant up-regulation.
The advent of new MS techniques coupled with 2D gel electrophoresis has resulted in the identification of numerous protein targets for cytotoxic agents that require metabolic activation; a current database of these targets shows many commonalities (Fang et al. 2009).
Each of the transcripts representing these targets shows 70 85% identity over more than 70% of its length to a known human disease related gene or protein found by sequence similarity comparisons (see Methods).
All these targets showed induced expression levels (except CREB1) in MSDACs (compared to parental SH-SY5Y) and manifold of metastatic tumors (compared with non-metastatic xenograft) as examined with immunoblotting.
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