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Appreciation of these studies requires an assessment of the design and adequacy of variables measuring exposures, outcomes, and confounders.
Extrapolation of these studies requires greater integration of the site-specific field results with the current generation of process models.
The analysis of these studies requires merging across GWAS datasets as well as patient and marker selection.
The implementation of the complex workflows associated with these studies requires provenance-based quality control to ensure the accuracy, reproducibility, and reusability of the data and analysis protocols.
The incongruence in these studies requires further exploration.
Validation of these studies requires large collaborative efforts.
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These studies require validation in larger, adequately powered trials.
These studies required large numbers of patients and cost several million dollars apiece. Nearly 400 of them had been completed by 2009.
Given the usual lack of direct benefit, ethicists say, these studies require particularly close monitoring, because they can pose a risk to a volunteer's health or life.
These studies require that naturally occurring enzymes be redesigned to recognize novel target sites.
These studies require the use of validated endpoints to measure specific symptom relief as well as accompanying quality of life.
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