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These include the modification of anthracycline-induced cardiotoxicity, immunemediated destruction of cardiomyocytes, the effects on HER2 signaling pathways that are required for the maintenance of normal cardiac contractility, and the dependence on HER2 for myocyte survival, which is then impaired during trastuzumab treatment [ 27].
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These include the hyper-modification of tRNA bases; a new biosynthetic pathway to menaquinone (vitamin K) that operates in some bacteria, and in the biosynthetic pathway for coenzyme F420.
These include the post-translational modification of histones (Kouzarides, 2007) and the action of ATP-dependent chromatin remodelling enzymes (Becker and Horz, 2002).
These include the extreme evolutionary modifications and adaptations that have accompanied the formation of organelles in eukaryotic cells: plastids and mitochondria.
Supportive mechanisms were developed to assist these nurses in their role, including the modification of clinical data collection forms, checklists and job aides to guide the process of data collection [ 47] and clear processes for setting up contracts with patients for disease management [ 44].
In November 1939, the ship returned to the Blohm & Voss dockyard for modifications; these included the replacement of the straight stem with a clipper bow and the installation of the funnel cap.
These may include the chemical modification of DNA (genomic imprinting) or interference of messenger RNA.
These include modification of the atmospheric electric potential structure over thunderstorm regions and the possible stimulation of high-altitude-lightning, as well as studies of relativistic electron precipitation effects on chemical reaction paths.
These include modifications of the active immunization approach that will hopefully not trigger encephalitis.
These effects include the amplitude-dependent modifications of the Josephson inductance, as well as the gain compression of the incremental response.
These mechanisms include the post translational modifications of histones and ATP-dependent chromatin remodelling.
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