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"Banks are worried about interpretations of these guidances, so they're still waiting for others to test the water".
These guidances likely would not have been issued if the federal regulators had viewed the issues they addressed as being isolated to a few banks.
These guidances demonstrate the need for innovation and flexibility in developing products for conditions with a major unmet medical need, such as NASH.
Although the context for the FDA and EMA documents is to develop PRO instruments to support labelling, there are some methods in these guidances that may apply to non-labelling objectives.
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We regret that these guidance notes have not been available in braille.
These guidance strategies are typically based on the lateral error of the center of gravity (CoG).
These Guidance and Guidelines were not explicitly developed for REDD+, although this may be envisaged in the near future.
In the past decades, a lot of studies focused on these guidance cues singly or doubly using genetically knock-out mice or blocking technology, and little attention is paid to the relationship between these guidance cues or the pathways related to these cues.
Modelled BLLs based on these guidance values (assuming median wine consumption rate) did not exceed 5 μg/dL, suggesting that these current limits are protective of health under the examined average exposure scenario (Table 6).
"These guidance documents simply suggest that prosecutors and bank regulators might 'look the other way' if financial institutions don't mind violating the law," Jackson said.
I appreciate that these guidance documents predate Dr. King's service with the Department, and that he had no role in their development or issuance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com