Therefore, under physiological conditions, Sema3-Nrp mediated PKA inhibition promotes Gli2 translocation to the cilia tips.
Therefore, under physiological conditions, Ppn1 probably degrades the long-chain polymer to short-chain polyphosphate of more than 20 phosphate residues, which is known to be required for the growth of yeast in minimal medium [ 59].
Therefore, under the physiological conditions intracellular TG2 predominantly exists as a catalytically inactive protein due to low calcium and inhibitory effect of GTP [37].
Therefore, under normal physiological conditions, IgG induces cancer cells to produce ROS at low level but not at moderate or high level through inhibiting the above antioxidant system, as the latter two are not beneficial to cancer cell growth.
Therefore, under normal physiological conditions, the control of strictosidine vacuolar efflux could insure that the level of activated dialdehyde, produced following strictosidine deglucosylation in the nucleus, is not too high to be fully metabolised by the following steps of the MIA biosynthetic pathway.
Therefore, autophagy occurs under physiological conditions without being affected by external nutrient availability in C. elegans embryos.
We therefore conclude that, under physiological conditions, truncation of the C-terminus of Cav1.4 results in a loss-of-function because the truncated channels are incapable of supporting continuous calcium influx during changes in illumination.
This regulatory mechanism may therefore be required under physiological conditions to prevent over-activation of the channels and may have evolved in vertebrates as an additional mechanism to protect cells against Ca2+ toxicity.
The recent reports therefore suggest that under physiological conditions, both the expression levels of CD95L and the threshold levels for CD95 "signal conversion" might be more relevant for the regulation and fine-tuning of the immune response than hitherto anticipated.
Therefore, under a given physiological state, either the central anorexigenic or the peripheral orexigenic TrkB system could dominate the metabolic outcome dependent on the relative levels of receptor activation (Fig. 4g).
The interaction of MA with DNA is stable at least up to 200 mM NaCl and is therefore expected to occur under physiological conditions; indeed we found it necessary to include 500 mM NaCl in buffers during the early stages of purification to prevent co-purification with DNA.
