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The first of these is by activation of intravenous 5-fluoruracil or oral capecitabine through conversion to active metabolites; the second mechanism is by abrogating thymidine rescue in methotrexate regimens and therefore salvaging the methotrexate block on de novo DNA synthesis.
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Therefore, salvage mastectomy has to be performed, or even more extensive surgery when the chest wall is involved.
Therefore, salvage of a recurrent region or treatment of a new region with further partial-gland brachytherapy could potentially be done so long as the combined normal tissue constraints are met.
Therefore, aggressive salvage treatment should be considered if the general condition of the patient allows it.
Therefore, further salvage therapies and consolidating high-dose therapy followed by either autologous or allogeneic stem cell transplantations in eight and five patients were applied.
Therefore, a salvage regimen is likely to be more complicated in that it may require multiple ARVs with partial residual activity and compromised genetic barriers of resistance to attain complete virological suppression.
Therefore, a salvage regimen should optimally have three fully active ARVs.[ 28] In patients with complicated treatment histories, genotypic and/or phenotypic susceptibility testing is often not sufficient to identify drug-resistant variants that emerged during past therapies and may still pose a threat to a new regimen.
Therefore, antioxidative and anti-inflammatory responses may be vital for preventing apoptosis, salvaging the myocardium, preserving heart function and reversing cardiac remodelling.
Therefore, after internalization, the cholesterol requirement by Leishmania for its sustenance may be fulfilled by salvaging cholesterol from host macrophages.
Salvaging the Costa Concordia.
Both were instrumental in salvaging the Tobacco Price Support Program.
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