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Therefore, salvage mastectomy has to be performed, or even more extensive surgery when the chest wall is involved.
Therefore, salvage of a recurrent region or treatment of a new region with further partial-gland brachytherapy could potentially be done so long as the combined normal tissue constraints are met.
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The first of these is by activation of intravenous 5-fluoruracil or oral capecitabine through conversion to active metabolites; the second mechanism is by abrogating thymidine rescue in methotrexate regimens and therefore salvaging the methotrexate block on de novo DNA synthesis.
Therefore, aggressive salvage treatment should be considered if the general condition of the patient allows it.
Therefore, further salvage therapies and consolidating high-dose therapy followed by either autologous or allogeneic stem cell transplantations in eight and five patients were applied.
Therefore, a salvage regimen is likely to be more complicated in that it may require multiple ARVs with partial residual activity and compromised genetic barriers of resistance to attain complete virological suppression.
Therefore, a salvage regimen should optimally have three fully active ARVs.[ 28] In patients with complicated treatment histories, genotypic and/or phenotypic susceptibility testing is often not sufficient to identify drug-resistant variants that emerged during past therapies and may still pose a threat to a new regimen.
Therefore, the NAD+ salvage pathway and the amount of NAD+ in the liver were analyzed to clarify the regulation of SIRT1 activity in the NBNC liver.
Of the 5 patients (10%) (all without a SLNB) with a partial response (PR) 4 developed distant metastases within 1 year of initial treatment and therefore refrained from salvage surgery.
Mycoplasmas cannot de novo synthesize purines and pyrimidines; therefore, they depend on salvage and interconversions to supply the cell with the nucleic acid precursors [ 82].
These findings question the use of T2-weighted MRI to measure the area-at-risk or to index myocardial salvage; and therefore, conclusions previously based on this premise in clinical practice, multicenter trials, and basic investigations should be re-examined.
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