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Via Arp2/3 inhibition, PICK1 has complementary yet distinct roles during LTD to regulate AMPA receptor trafficking and spine size, and therefore functions as a crucial factor in both structural and functional plasticity.
The NF-κB pathway is a paradigm of how caspase cleavage may result in a complete loss of the transcription factor's antiapoptotic function: (i) Cleavage of NF-κB subunit p65 (RelA) generates a dominant-negative fragment that is still able to bind to DNA but looses its transactivating activity, and therefore functions as a dominant-negative inhibitor.
Forced expression of dominant-negative LRP5 (dnLRP5), which lacks the membrane binding domain of the native protein and therefore functions as a soluble receptor-sponge for Wnt ligands, reduced in vitro cellular invasion and in vivo xenograft tumor growth for osteosarcoma cell lines.
Basic income therefore functions as a floor.
The Ras pathway therefore functions as a supersensitive threshold detector for neural activity and Ca(2+) concentration.
The serotonin 5HT1c receptor therefore functions as a protooncogene when expressed in NIH 3T3 fibroblasts.
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The proposed ITO materials could therefore function as omnidirectional anti-reflection materials and super hydrophobic surface.
Furthermore, it does not require any electronic devices or external power supplies, therefore functioning as a non-contacting passive damper.
Our approach assessed the pattern and characteristics of "hydrologic facets" (landscape patches that have high internal surface water connectivity and therefore function as a single hydrologic unit), where facet boundaries were defined by subtle topographic divides across the floodplain.
Phablets are typically classed as smartphones with screens of 5 inches or more on the diagonal, which can therefore function as small tablets.
Statistics could therefore function as a bridge connecting a part of mathematics with the sciences.
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