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"therefore first of all" is a correct and usable phrase in written English.
You can use it to introduce a logical conclusion or the first step towards an action. For example: "The meeting did not reach a consensus. Therefore, first of all, we need to re-examine the proposal."
Exact(7)
In order to identify who is incumbent and who is the challenger, it is therefore first of all necessary to identify what the field is all about.
We therefore first of all used subsamples for relevant waves to check if the measure inconsistency causes any divergence in analysis and found no prominent difference in the role of perceived mobility.
The specific task of Fichte's ethics is therefore, first of all, to deduce the categorical imperative (in its distinctively moral sense) from the general obligation to determine oneself freely, and, second, to deduce from this the particular obligations that apply to every free and finite rational being.
Therefore, first of all, we will discuss whether biguanides reduce weight and affect body composition (fat vs. lean mass and visceral vs. subcutaneous fat).
Therefore, first of all, negative targets were extracted as the up-regulated genes in 20 microarray data due to miRNA over-expression from NCBI Gene Expression Omnibus (GEO).
It is most difficult to reduce the consequence of a threat; the focus should therefore first of all be on reduction of likelihood.
Similar(53)
Regarding TBPH, therefore, we first of all wanted to determine whether reduced expression of futsch protein in our TDP-43 minus flies could be directly related to a reduction in the mRNA levels of these factors.
This realization is extremely difficult to achieve and therefore Sāṃkhya proposes first of all to clear the mind of the passions [SSu 2.15] by separating them from cognition and then to free the mind from cognition in order to comprehend contentless consciousness.
Therefore, first, all threads of question/answer must be evacuated and then those posts related to specific user can be extracted from this threads.
The critical point in the development of the empirical analysis was, therefore, to prove first of all the existence of a possible correlation between the accumulation of knowledge (of which the cognitive script acquisition is a direct expression) and the propensity to spin off, linked to a precise determination of the new entrepreneur to reproduce the parent company's cognitive map.
38% of the MRI results were BI-RADS 6-lesions and were therefore histologically confirmed first of all.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com